Clinically, 40% to 60% of patients acquired DVT after orthopedic surgery 4% to 10% of those patients developed pulmonary embolism (PE), of which 5% die 1. Major surgery and orthopedic surgery, as acquired risk factors, carry a substantial risk of DVT. Our results demonstrate additional evidence supporting that there is an important role for the KNG1 and BDKRB2 genes in the increased susceptibility of DVTAOS.ĭeep venous thrombosis (DVT) is a common disorder, in which is a blood clot occurs inside a vein DVT has several risk factors, including acquired, inherited and mixed. Moreover, bioinformatics analysis indicated that hsa-miR-758-5p and BDKRB2 formed miRNA/SNP target duplexes if the rs2069588 allele was in the T form, suggesting that rs2069588 may alter BDKRB2 expression by affecting hsa-miR-758-5p/single-nucleotide polymorphism target duplexes. Haplotype analyses showed that an LD block containing rs2069588 significantly correlated with the DVTAOS risk. After adjusting for BMI, the significance of rs2069588 decreased ( P = 0.0013).
A total of 3,010 study subjects comprising 892 DVT cases and 2,118 controls were included in the study, and 39 single nucleotide polymorphisms (SNPs) in total (30 for BDKRB2 and 9 for KNG1) were chosen for genotyping. In this study, we aimed to investigate the potential association in the Han Chinese population between the polymorphisms of BDKRB2 and KNG1 and DVT after orthopedic surgery (DVTAOS).
Genetic risk factors and high heritability carried a substantial risk of DVT. Deep venous thrombosis (DVT) is a common complication of orthopedic surgery.
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